Developing the first protein-replacement therapy for patients with Dystrophic Epidermolysis Bullosa.

Phoenix Tissue Repair is advancing a novel treatment for Dystrophic Epidermolysis Bullosa (DEB), a rare skin disease resulting from a deficiency of human collagen type VII.


Collagen is an essential component of human skin and connective tissues. More than two-dozen types of collagen exist in the body, each one playing its own distinct and important role. Collagen type VII functions as nature’s Velcro, forming anchoring fibrils that secure the skin’s protective outer layer, the epidermis, to the thick under-layer known as the dermis. Mutations in the gene that encodes collagen type VII can disrupt its ability to anchor the epidermis, resulting in a genetic disease called Dystrophic Epidermolysis Bullosa (DEB). The disease can also affect the lining of the mouth, esophagus, eye, anus and vagina.

Two forms of the disease exist, based on how it is inherited. In the United States, the recessive and dominant forms of DEB each have a prevalence of one affected patient per million people. There is currently no cure or effective treatment available to patients.


In patients with DEB, the epidermis can separate from the dermis. Even minor friction or trauma can cause debilitating blistering, tearing and scarring of the skin, along with severe pain and itching. The internal skin lining the mouth and throat are affected, disrupting patients’ ability to eat. Many die prematurely from aggressive squamous cell carcinoma, a common complication of DEB. These patients have no treatment options beyond daily wound care, pain management and protective bandaging. The epidermolysis bullosa patient community has done extraordinary work to spread awareness of the unmet medical need that patients face.

Phoenix Tissue Repair is working to create a first-ever treatment for DEB by replacing the collagen proteins at the root of the disease.

About rCol7

Phoenix Tissue Repair is advancing an investigational therapy known as recombinant collagen VII (rCol7) for the treatment of Dystrophic Epidermolysis Bullosa. rCol7 is a potentially disease-modifying drug that’s delivered intravenously to patients, replacing defective collagen VII with healthy collagen at the sites where it is needed.

Phoenix Tissue Repair acquired worldwide rights to rCol7 from Shire Plc in 2017 and is currently preparing to initiate its first clinical trial. Preclinical studies of rCol7 have shown that it selectively anchors in the skin and other tissues affected by an absence of collagen VII. In four animal models of the disease, intravenous injections of rCol7 promoted healing of DEB wounds.

These experiments have shown improvements in tissue structure, disease presentation and survival, indicating a restoration of natural skin architecture.


Neil Kirby, Ph.D.

President and Chief Executive Officer

Ramsey Johnson

VP, Operations

Becky Dabora, Ph.D.

Senior VP Technical Operations

Theresa Podrebarac, Ph.D.

Chief Medical Officer

Le-Yi Wang, Ph.D.

Vice President of Business Development and Operations

About Us

Phoenix Tissue Repair is passionate about bringing forth a safe and effective drug for patients with Dystrophic Epidermolysis Bullosa (DEB), a rare genetic disease affecting the skin and other organs.

Our dedicated team is working to develop a treatment option that will provide appropriate replacement of the deficient collagen 7 protein to the patients’ skin and other tissues affected by this devastating disease. Investigational drug rCol7 represents the only potentially disease-modifying treatment in development that may solve the systemic manifestations of DEB as well as the more visible skin related aspects of the disease.


Phoenix is part of the BridgeBio family. BridgeBio is a clinical-stage biotech company developing novel, genetically targeted therapies to improve the lives of patients. The BridgeBio approach combines a traditional focus on drug development with a unique corporate model, allowing rapid translation of early stage science into medicines that treat disease at its source. Founded in 2015 by a team of industry veterans, the company has built a robust portfolio of nineteen transformative assets, each housed in its own subsidiary, ranging from pre-clinical to late stage development in multiple therapeutic areas including dermatology, cardiology, oncology and endocrinology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines.


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